Before Joining Stanford:

*-co-first authors #-co-corresponding authors

Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Mills EL, Chouchani ET. Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.

Nature Metabolism, 2024. 6, 567-577.

Rahbani JF, Bunk J, Lagarde L, Samborska B, Roesler A, Xiao H, Shaw A, Kaiser Z, Braun JL, Geromella MS, Marcella BM, Fajardo VA, and Kazak L. Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.

Cell Metabolism, 2024, 36(3), 526-540.

Liu W, Wang Y, Bozi, LHM, Fischer P, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao J, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Lactate Regulates Cell Cycle by Remodeling the Anaphase Promoting Complex.

Nature. 2023. 616 (7958), 790-797.

Darabedian N, Ji W, Fan M, Lin S, Seo HS, Vinogradova EV, Yaron TM, Mills EL, Xiao H, Senkane K, Huntsman EM, Johnson JL, Che J, Cantley LC, Cravatt BF, Dhe-Paganon S, Stegmaier K, Zhang T, Gray NS, Chouchani ET.Depletion of Creatine Phosphagen Energetics with A Covalent Creatine Kinase Inhibitor.

Nature Chemical Biology. 2023. 19, 815-824.

Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, Mu A, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM. Isolation of Extracellular Fluids Reveals Novel Secreted Bioactive Proteins from Muscle and Fat Tissues.

Cell Metabolism. 2023. 35 (3), 535-549. e7.

Devant P, Boršić E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovič I, Evavold CL, Kagan JC. Gasdermin D Pore-Forming Activity is Redox-Sensitive.

Cell Reports. 2023;42(1):112008.

Xiao H*#, Bozi LHM*, Sun YZ*, Riley CL*, Philip VM, Chen M, Li JM, Zhang T, Mills EL, Emont MP, Sun WF, Reddy A, Garrity R, Long JN, Becher, T, Vaites LP, Laznik-Bogoslavski D, Ordonez M, Liu XY, Chen X, Wang Y, Liu WH, Tran N, Liu YT, Zhang Y, Cypess AM, White AP, He YC, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET#. Architecture of the Outbred Brown Fat Proteome Defines Regulators of Metabolic Physiology.

Cell. 2022. 185(24), 4654-4673.

Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Cysteine 253 of UCP1 Regulates Energy Expenditure and Sex-dependent Adipose Tissue Inflammation.

Cell Metabolism. 2022;34(1):140-57.

Xu SH, Zheng JN, Xiao H, Wu RH. Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.

Analytical Chemistry. 2022;94(7):3343-51.

Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED. IRF3 Reduces Adipose Thermogenesis via ISG15-Mediated Reprogramming of Glycolysis.

Journal of Clinical Investigation. 2021;131(7).

Mills EL, Xiao H, Chouchani ET. AIDA and UCP1 Snuggle Up to Prevent Hypothermia.

Nature Cell Biology. 2021;23(3):216-8. (Commentary article)

Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. UCP1 Governs Liver Extracellular Succinate and Inflammatory Pathogenesis.

Nature Metabolism. 2021;3(5):604-17.

Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho LL, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Ryde'n M, Saltiel AR. Glycogen Metabolism Links Glucose Homeostasis to Thermogenesis in Adipocytes.

Nature. 2021;599(7884):296-301.

Xiao H*, Jedrychowski MP*, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li JM, Long JN, Mills EL, Szpyt J, He ZX, Du GY, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang TH, Gray NS, Gygi SP, Chouchani ET. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. 

Cell. 2020;180(5):968-83.

Yu Q, Xiao H, Jedrychowski MP, Schweppe DK, Navarrete-Perea J, Knott J, Rogers J, Chouchani ET, Gygi SP. Sample Multiplexing for Targeted Pathway Proteomics in Aging Mice.

Proceedings of the National Academy of Sciences of the United States of America. 2020;117(18):9723-32.

Tong M, Smeekens JM, Xiao H, Wu RH. Systematic Quantification of the Dynamics of Newly Synthesized Proteins Unveiling Their Degradation Pathways in Human Cells.

Chemical Science. 2020;11(13):3557-68.

Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, Nicholson HE, Paschini M, Paulo JA, Garrity R, Laznik-Bogoslavski D, Ferreira JCB, Carl CS, Sjoberg KA, Wojtaszewski JFP, Jeppesen JF, Kiens B, Gygi SP, Richter EA, Mathis D, Chouchani ET. pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.

Cell. 2020;183(1):62-75.

Xiao H, Sun FX, Suttapitugsakul S, Wu RH. Global and Site-Specific Analysis of Protein Glycosylation in Complex Biological Systems with Mass Spectrometry.

Mass Spectrometry Reviews. 2019;38(4-5):356-79. (Review article)

Suttapitugsakul, S., Xiao H, Wu RH. Identification and Quantification of Newly Synthesized Proteins Using Mass Spectrometry‐Based Chemical Proteomics. (Book chapter)

Mass Spectrometry‐Based Chemical Proteomics. 2019;207-229.

Sun FX, Suttapitugsakul S, Xiao H, Wu RH. Comprehensive Analysis of Protein Glycation Reveals Its Potential Impacts on Protein Degradation and Gene Expression in Human Cells.

Journal of the American Society for Mass Spectrometry. 2019;30(12):2480-90.

Xiao H*, Chen WX*, Smeekens JM, Wu RH. An Enrichment Method Based on Synergistic and Reversible Covalent Interactions for Large-Scale Analysis of Glycoproteins.

Nature Communications. 2018;9.

Xiao H, Suttapitugsakul S, Sun FX, Wu RH. Mass Spectrometry-Based Chemical and Enzymatic Methods for Global Analysis of Protein Glycosylation.

Accounts of Chemical Research. 2018;51(8):1796-806. (Review article)

Xiao H, Hwang JE, Wu RH. Mass Spectrometric Analysis of the N-Glycoproteome in Statin-Treated Liver Cells with Two Lectin-Independent Chemical Enrichment Methods.

International Journal of Mass Spectrometry. 2018;429:66-75.

Nguyen DC, Lewis HC, Joyner C, Warren V, Xiao H, Kissick HT, Wu RH, Galipeau J, Lee FEH. Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stromal Cells Support Ex Vivo Survival of Human Antibody Secreting Cells.

Journal of Extracellular Vesicles. 2018;7(1).

Nguyen DC, Garimalla S, Xiao H, Kyu S, Albizua I, Galipeau J, Chiang KY, Waller EK, Wu RH, Gibson G, Roberson J, Lund FE, Randall TD, Sanz I, Lee FEH. Factors of the Bone Marrow Microniche that Support Human Plasma Cell Survival and Immunoglobulin Secretion.

Nature Communications. 2018;9.

Zheng JN, Xiao H, Wu RH. Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells.

Angewandte Chemie-International Edition. 2017;56(25):7107-11.

Zhang MN, Matyunina LV, Walker LD, Chen WX, Xiao H, Benigno BB, Wu RH, McDonald JF. Evidence for the Importance of Post-Transcriptional Regulatory Changes in Ovarian Cancer Progression and the Contribution of miRNAs.

Scientific Reports. 2017;7.

Xiao H, Wu RH. Quantitative Investigation of Human Cell Surface N-Glycoprotein Dynamics.

Chemical Science. 2017;8(1):268-77.

Xiao H, Wu RH. Global and Site-Specific Analysis Revealing Unexpected and Extensive Protein S-GlcNAcylation in Human Cells.

Analytical Chemistry. 2017;89(6):3656-63.

Xiao H, Wu RH. Simultaneous Quantitation of Glycoprotein Degradation and Synthesis Rates by Integrating Isotope Labeling, Chemical Enrichment, and Multiplexed Proteomics.

Analytical Chemistry. 2017;89(19):10361-7.

Suttapitugsakul S, Xiao H, Smeekens J, Wu RH. Evaluation and Optimization of Reduction and Alkylation Methods to Maximize Peptide Identification with MS-Based Proteomics.

Molecular Biosystems. 2017;13(12):2574-82.

Smeekens JM, Xiao H, Wu RH. Global Analysis of Secreted Proteins and Glycoproteins in Saccharomyces cerevisiae.

Journal of Proteome Research. 2017;16(2):1039-49.

Ali MRK, Wu Y, Tang Y, Xiao H, Chen KC, Han TG, Fang N, Wu RH, El-Sayed MA. Targeting Cancer Cell Integrins Using Gold Nanorods in Photothermal Therapy Inhibits Migration through Affecting Cytoskeletal Proteins.

Proceedings of the National Academy of Sciences of the United States of America. 2017;114(28):E5655-E63.

Ali MRK, Rahman MA, Wu Y, Han TG, Mackeya MH, Mackey MA, Wang DS, Shin HJ, Chen ZG, Xiao H, Wu RH, Tang Y, Shin DM, El-Sayed MA. Efficacy, Long-Term Toxicity, and Mechanistic Studies of Gold Nanorods Photothermal Therapy of Cancer in Xenograft Mice.

Proceedings of the National Academy of Sciences of the United States of America. 2017;114(15):E3110-E8.

Xiao H, Tang GX, Wu RH. Site-Specific Quantification of Surface N-Glycoproteins in Statin-Treated Liver Cells.

Analytical Chemistry. 2016;88(6):3324-32.

Xiao H, Smeekens JM, Wu RH. Quantification of Tunicamycin-Induced Protein Expression and N-Glycosylation Changes in Yeast.

Analyst. 2016;141(12):3737-45.

Ali MRK, Wu Y, Hang TG, Zang XL, Xiao H, Tang Y, Wu RH, Fernandez FM, El-Sayed MA. Simultaneous Time-Dependent Surface-Enhanced Raman Spectroscopy, Metabolomics, and Proteomics Reveal Cancer Cell Death Mechanisms Associated with Gold Nanorod Photothermal Therapy.

Journal of the American Chemical Society. 2016;138(47):15434-42.

Xiao H, Tang GX, Chen WX, Wu, RH. A Boronic Acid-Based Enrichment for Site-Specific Identification of the N-Glycoproteome Using MS-Based Proteomics. (Book chapter)

Analysis of Post-Translational Modifications and Proteolysis in Neuroscience. 2015;31-41.

Xiao H, Chen WX, Tang GX, Smeekens JM, Wu RH. Systematic Investigation of Cellular Response and Pleiotropic Effects in Atorvastatin-Treated Liver Cells by MS-Based Proteomics.

Journal of Proteome Research. 2015;14(3):1600-11.